Chelorex Chelation & Supplement Formulations

Broad Spectrum Chelating Formulation

CHELOREX™ is an all natural, physician-formulated oral chelation product designed specifically for chronic metal poisoning. Chronic metal poisoning (CMP) represents about 98% of all toxic metal poisoning. It differs from acute metal poisoning (AMP) in that: chronic metal poisoning occurs as a result of prolonged exposure to multiple toxic metals. It usually develops insidiously with gradual onset of symptoms, often barely noticed. AMP occurs suddenly with obvious symptoms, often due to exposure to a single toxic metal. It is a new, safe, effective, convenient, and less expensive approach to heavy (toxic) metal chelation.

Effects of Chronic Heavy Metal Poisoning

Chronic metal poisoning is associated with depletion of essential trace minerals and of glutathione and other antioxidants resulting in:

1) Impairment of chemical detoxification mechanisms with associated chemical sensitivities (MCS).

2) Impaired thyroid function due to inability to convert T4 to T3.

3) Mitochondrial dysfunction and impaired oxidative phosphorylation, excessive free radical formation and the release of inflammatory cytokines. This results in fatigue, pain and inflammation, impaired immune function, susceptibility to chronic degenerative disease, accelerated aging, and less than optimal mental and physical functioning.

Synthetic chelation agents such as DMPS and DMSA were formulated for acute metal poisoning (AMP). While they are able to mobilize large amounts of lead, mercury and other metals, they contain no antioxidants to protect the body and have a high incidence of moderate to severe adverse side effects, especially in persons with multiple chemical sensitivities or previously existing liver or kidney damage.

Questions & Answers

Why is CHELOREX™ the best choice for oral chelation?

A: 1) Contains no synthetic chelating agents, therefore no dangerous adverse reactions (synthetic chelation agents produce moderate to severe adverse responses in 30% of persons undergoing chelation.)

2) Enhances your body's natural detoxification mechanisms via multiple routes.

3) Provides support for chemical detoxification by stimulating glutathione synthesis and providing selenium, magnesium and zinc.

4) Natural effective mobilization of toxic metals while avoiding toxic overload of liver and kidneys seen with synthetic chelators.

5) Provides antioxidant protection against free radicals.

6) Marked enhancement of GI excretion with bowel protection.

7) Safe for chemically sensitive persons.

8) No EDTA avoids risk of neurotoxic complex with mercury.

9) Effective for entire spectrum of toxic metals.

10) Most cost effective of all chelators.

11) Only oral chelating agent with clinical studies showing excellent ability to reduce levels of all toxic metals in hair while markedly enhancing urinary and fecal excretion. Other oral chelation agents have no comparable studies (most have no studies at all) or have inadequate levels of chelating agents to be effective.

12) Can be used for long-term protection for persons who must sustain chronic environmental exposure.

13) Contains both water-soluble agents and lipid soluble agents, capable of penetrating the blood-brain barrier and cellular membranes.

In what ways is CHELOREX™ superior to IV chelation?

A:
1) CHELOREX™ can be used safely at home, even in persons with amalgam fillings.

2) A 90 dose course of oral chelation with CHELOREX™ costs a small fraction of the price of IV chelation ($210-280 vs $3000-5000)

3) Because CHELOREX™ contains no synthetic chemicals, it can be used safely in chemically sensitive people.

4) Oral chelation with CHELOREX™ avoids the discomfort of IV needles and the inconvenience of going to a doctor's office or clinic, this is especially welcome news for persons who have poor veins or are markedly overweight.

5) CHELOREX™ can be used daily and for long periods with appropriate monitoring by hair analysis.

6) CHELOREX™ has no serious adverse side effects.

7) CHELOREX™ enhances excretion by multiple pathways ­ intestinal tract, hair, perspiration and urinary tract ­ thus avoiding damage to kidney function

8) CHELOREX™ does not require a prescription.

9) Trace mineral depletion is minimized.

10) CHELOREX™ can be used to protect the body during amalgam replacement.

11) Multiple components of CHELOREX™ have been shown to protect mitochondrial function.

12) Oral chelation with CHELOREX™ avoids the problems of toxic redistribution of metals seen with DMPS.

13) CHELOREX™ removes the full spectrum of toxic metals. Study shows that CHELOREX removed 99% of heavy metals in as little as 45 days.

14) CHELOREX™ supports central and peripheral nervous system function.

How is CHELOREX™ superior to other supplements including EDTA?

A:
1) EDTA forms a neurotoxic complex with mercury which prevents the polymerization of tubulin in the nervous system. (See Duhr, et al. HgEDTA complex inhibits GTP interactions with the E site of brain beta-tubulin. Toxicol Appl Pharmacol 122(2): 273-280 (1993).)

2) EDTA is a narrow spectrum chelation agent which removes primarily lead and calcium. CHELOREX™ has been shown to remove the entire spectrum of toxic metals from aluminum to uranium. This is important because the presence of multiple toxic metals significantly lowers the toxic threshold for each toxic metal present. For example, a given level of mercury will be more toxic if lead is also present and both these levels will be more toxic at a lower level if arsenic or cadmium are also present.

3) EDTA is known to be poorly absorbed from the gastro-intestinal tract, reducing its effectiveness in the oral form.

4) CHELOREX™ contains both water soluble and lipid soluble components allowing it to penetrate the blood-brain barrier and cell membrane as well as the extra-cellular space. EDTA has never been shown to penetrate the blood-brain barrier.

Availability

540 caplets and 32 oz liquid

How Much Chelorex Do You Need?

For Maximum Results we recommend a minimum of 90 (ninety) doses, the same dosing amount used in Dr. Alan Greenberg's ongoing studies.
Use this chart to determine the correct amount of Chelorex™ to order

Body
Weight
Amount of Caplets per Dose   Amount of Caplets for 90 Doses  Amount of
Chelorex™
100-105 lbs 10 Caplets 900 Caplets 2 Bottles
106-115 lbs 11 Caplets 990 Caplets 2 Bottles
116-125 lbs 12 Caplets 1080 Caplets 2 Bottles
126-135 lbs 13 Caplets 1170 Caplets 3 Bottles
136-145 lbs 14 Caplets 1260 Caplets 3 Bottles
146-155 lbs 15 Caplets 1350 Caplets 3 Bottles
156-165 lbs 16 Caplets 1440 Caplets 3 Bottles
166-175 lbs 17 Caplets 1530 Caplets 3 Bottles
176 lbs
&
above
18 Caplets 1620 Caplets 3 Bottles

CHELOREX™ 540 Caplets per Bottle

ADULT DIRECTIONS: Take with meals or food and with sufficient liquid to swallow. Do not swallow all caplets at once. Do not exceed 18 caplets per dose; even if you weigh more than 180 lbs. Do not exceed 36 caplets daily

For Chelorex™ Maximum Results:
Morning Dosage: 1 caplet per 10 lbs. of body weight
(Up to 18 caplets)
Evening Dosage: 1 caplet per 10 lbs. of body weight
(Up to 18 caplets)

Example 1: A 180 lb. (and above) person would take 18 caplet dose in the morning & a 18 caplet dose in the evening for 45 days or you may take one morning or evening dose per day for 90 days.

Example 2: A 120 lb. person would take 12 caplet dose in the morning & a 12 caplet dose in the evening for 45 days or you may take one morning or evening dose per day for 90 days.

Drink: 6-8 glasses of pure water per day.
Eat: A whole food, high fiber, low fat and low refined carbohydrate diet.

Maintenance Dosage: 2-6 caplets daily
 

Chelorex Liquid 32 oz

Chelorex Liquid offers a convenient body weight- based application:

If you weigh between 90 and 134 lbs . . . you would take one ounce twice a day. Three bottles will give you 90 applications (45 days -- 1 ounce twice a day).

If you weigh between 135 and 179 lbs . . . you would take 1.5 ounces twice a day. 4-5 bottles will provide you with the 90 applications (45 days -- 1.5 ounces twice a day).

If you weigh 180 lbs and above . . . you would take 2 ounces twice a day. 5-6 bottles will provide you with the 90 applications (45 days -- 2 ounces twice a day).  

Ingredients

Chelorex Caplets: Vitamins C & E, Magnesium, Zinc, Selenium, MSM, Cracked Cell Chlorella, N-Acetyl-L-Cysteine, L-Glutamine, Taurine, Cilantro Leaf Extract, Alpha Lipoic Acid. Other ingredients: Dicalcium phosphate, cellulose, croscarmellose sodium, stearic acid, magnesium stearate, silica, food glaze.
For further details, go to:
http://www.globallight.net/Chelorex-Multi-Formula_p11.html
 

Chelorex Liquid

cilantro leaf extract
MSM
taurine
l-glutamine
vitamin D (as d-alpha tocopherol with mixed tocopherols)
magnesium (as magnesium lactate gluconate)
cracked cell chlorella extract
alpha lipoic acid
NAC (N-acetylcysteine)
vitamin C (as ascorbic acid)
zinc (as zinc gluconate)
selenium (as sodium selenate)
vitamin B6 (as pyridoxal 5' phosphate)
vitamin B12 (as methylcobalamin)
folic acid
D-ribose
stevia leaf extract
malic acid (from apples)
potassium phosphate
cranberry extract
milk thistle extract (80% Silymarin)
luo han guo fruit
coenzyme Q10
xylitol


Other ingredients: water, crystalline fructose, vegetable glycerin, xantham gum, natural flavors, potassium sorbate (to protect freshness) and sodium benzoate (to protect freshness).

This product contains no EDTA, DMPS, or DMSA.

Available Literature

Free DVD on Chelorex Oral Chelation (speaks of both formulations). Order your copy on our website under Books & CDs.

Introduction in Newsletter

A major theme of this week’s Newsletter is Depleted Uranium (DU) and the horrifying impact that it is having on populations all over the world. I have known for over 10 years that our military is using DU in their munitions when the US invades countries around the world . . . Iraq during the Gulf War, Afghanistan, and now Iraq again. That dreadful pollution will poison and/or kill occupants of those countries for generations to come . . . that would include our troops over there. However, there is growing evidence that the radiation poisoning is now spreading to other parts of the world . . . namely the UK and the US. As only one sign, the rates of lung cancer in the UK and the US is soaring.

We are all at risk from this radiation poisoning, whether or not we choose to become aware and whether or not we approve of the horrors in store for Mother Earth or for Mankind. To me, it is all beyond comprehension that our leaders would create this kind of devastation, but our responsibility is to become aware, do whatever we can to put a stop to it and learn of ways to protect ourselves and our loved ones. Today we are announcing an oral chelation product that has a multi-year proven track record of its ability to remove uranium poisoning from your body along with mercury and a plethora of other toxic metals. That product is CHELOREX. I have often said, jokingly, “I would rather be Lucky than Good.” Indeed, we are so lucky to have established a reciprocal relationship with Scientific Formulas, Inc, the developers of Chelorex. We are now carrying their two products, Chelorex and Multi, a chelation support supplement. They are representing our magnesium products at medical trade shows and introducing us to doctors, clinics and health food stores.

Newsletter Notes

• Regarding the article about tuna labels warning against mercury content, I believe that we will all be exposed to more and more mercury in our lives, with or without labeling, because mercury poisoning is becoming so pervasive. To me, that fact simply underscores the importance of a simple and affordable chelation product like Chelorex. In addition to chelating a lot of mercury from your body, there are 19 other toxic metals that it will pull out. As soon as I return to Texas, I plan to start the 45-day Chelorex protocol. Although there is an alternative, less aggressive protocol that takes 90 days, the 45-day approach has proven to be more effective.

• Regarding the Chelorex product for oral chelation of heavy metals, the Membership is slowly beginning to respond to this product. I have felt like we all have an education issue regarding this product, and I am working with Science Formulas to develop some informational tools that we can offer for FREE. This is an important and a leading-edge product that is worthy of our attention. Based on the information that I have so far from Science Formulas, I realize that the hazards of heavy metals in our lives are extensive, whether or not we realize it and whether or not we choose to deal with it.

• Our initial interest in the Chelorex products, and their interest in ours, rose out of our mutual interest in protocols that will address the symptoms of Autism. As we have often documented in this Newsletter, there is a huge connection between Autism and mercury poisoning from vaccinations. Chelation can help remove that mercury but in the process can also remove magnesium, thus creating a need for magnesium supplementation, and that is where Chelorex and Magnesium Oil meet to address Autism. Additionally, if a client is deficient in magnesium, the effectiveness of chelation can be diminished, so the two products are really quite synergistic. Then comes the growing awareness of DU, and we are positioned to offer our Membership a solution to uranium poisoning. The well-known EDTA intravenous chelation can easily cost several thousand dollars while the Chelorex protocol for a 180 pound adult is only about $350 and much less for a child . . . dramatic savings with proven superior results . . . is that a bargain! Notice that I mentioned children . . . the protocol can be scaled down so that young children can also be safely treated.

Chelorex Multi Support Supplement

This is a companion product to Chelorex Broad Spectrum Chelation Formula

While Chelorex is very effective at removing heavy metals, it also may remove some nutrients you don’t want to lose. That’s why it’s important to supplement during your chelation program with Chelorex Multi Support.

Multi is a new state-of-the-art dietary supplement with 64 different forms of vitamins, minerals, trace minerals, phytonutrient concentrates, botanicals, essential oils and antioxidants (along with the nutrients described here below) in an easy-to-swallow, pleasantly herbal-scented tablet, that is quick dissolving, and with no unpleasant vitamin-like aftertaste.

Ingredients

Bioperine®, is a patented piperine black pepper extract (5 mg/6 tabs) that enhances bioavailability. Bioperine® is a registered trademark of Sabinsa Corporation.

Popular Prescription Chelation Agents:

EDTA - approved by the FDA for lead removal, DMSA – mercury and lead, DMPS - used for mercury and lead but does not have FDA approval.

DMSA and DMPS are not recommended in persons with amalgam fillings.

Non Prescription Chelation Agents (see below)

Warning: EDTA forms neurotoxic complex with mercury – not recommended in persons with amalgams or history of mercury exposure.

The Case for Safe and Effective Chelation. Multiple clinical studies have shown individual non-FDA regulated food and herbal supplement ingredients have been found to be extremely effective in removing multiple toxic metals. Below is a list of the individual ingredients in the current CHELOREX™ (Formerly Metal Flush) formula DG81P, along with a brief functional summary. A few chelation agents such as Science Formulas Inc.’s CHELOREX™

Chelorex offers various combinations of the above and other supportive ingredients in a single formula. Reduction of body burden as revealed by hair analysis before and after chelation is the best evidence of efficacy. Studies demonstrating increased levels of toxic metals being excreted in urine, or stools provide only an imprecise indication of excretion, but does not provide information regarding remaining toxic metal burden.

Availability

180 caplets

Usage

Available Literature

Free DVD on Chelorex Oral Chelation (speaks of both formulations).

References to Scientific reviews of Ingredients

Listed under each Formula Ingredient below is the mechanism and supporting reference.

Vitamin E (as d-alpha-tocopherol succinate):
Antioxidant, supports thyroid function: Chang, L.W , Gilbert,M and Sprecher,J: Modification of methylmercury neurotoxicity by vitamin E, Environ.Res. 1978;17:356-366

Selenium (as sodium selenite):

Enhances chemical detoxification, reduces toxicity of metals, necessary for conversion of T4 to T3 for normal thyroid function. Selenium is an important constituent of glutathione peroxidase, which breaks down toxic peroxides and free radicals. It has been shown to significantly reduce heavy metal toxicity. Yoneda S, Suzuki KT Detoxification of mercury by selenium by binding of equimolar Hg-Se complex to a specific plasma protein. Toxicol Appl Pharmacol 1997;143(2):274-280 Johansson E: Selenium and its protection against the effects of mercury and silver. J Trace Elements 1991;5:273-274Gailer J; George GN; Pickering IJ, et al. Structural Basis of the Antagonism between Inorganic Mercury and Selenium in Mammals. Chem Res Toxicol 2000 Nov 20;13(11):1135-1142

Vitamin C (as ascorbic acid):
Promotes excretion of toxic metals, essential antioxidant, supports thyroid function. Vitamin C is known to enhance the excretion of toxic metals in the gut and to protect against free radical damage Hill, CH. Interactions of vitamin C with lead and mercury. Ann N Y Acad Sci 1980;355:262-6 Yamini B, Sleight SD. Effects of ascorbic acid deficiency on methyl mercury dicyandiamide toxicosis in guinea pigs J Environ Pathol Toxicol Oncol 1984 Jul;5(4-5):139-50 Zorn NE, Smith JT A relationship between vitamin B12, folic acid, ascorbic acid, and mercury uptake and methylation. Life Sci 1990;47(2):167-73 Iyengar GV; Nair PP. Global outlook on nutrition and the environment: meeting the challenges of the next millennium. Sci Total Environ 2000 Apr 17;249(1-3):331-46.

Zinc (as zinc citrate):
Stimulates metallothionine, reduces toxicity of metals. Journal of Orthomolecular Psychiatry 7 (2):94-106 1978Flora SJ, Tandon SK: Beneficial effects of zinc supplementation during chelation treatment of lead intoxication in rats, Toxicology, 1990 Nov; 64(2):129-39

Magnesium
(as magnesium aspartate):
Aids in chelation, replaces lost or chelated magnesium, protects against free radical damage. Assists in removing lead and other toxic metals. Reduces free radical damage from radiation and toxic substances. 1) Chugh SN, Kolley T, Kakkar R, Chugh K, Sharma A., A critical evaluation of anti-peroxidant effect of intravenous magnesium in acute aluminum phosphide poisoning. 2) 235: Soldatovic D, Vujanovic D, Matovic V, Plamenac Z.
 
Compared effects of high oral Mg supplements and of EDTA chelating agent on chronic lead intoxication in rabbits. Magnes Res. 1997 Jun;10(2):127-33. PMID: 9368233, 3) 321: Soldatovic D, Matovic V, Vujanovic D. Prophylactic effect of high magnesium intake in rabbits exposed to prolonged lead intoxication. Magnes Res. 1993 Jun;6(2):145-8. PMID: 8274359

Alpha-Lipoic Acid:
Binds intracellular toxic metals, quenches free radicals and raises glutathione levels.

Alpha lipoic acid is a sulfur-containing co-factor for many essential biochemical reactions with potent antioxident properties. It is lipid and water soluble and can penetrate the blood brain barrier. This helps to remove toxic metals from the CNS. Ziegler C, et al: Alpha-lipoic acid in the treatment of diabetic neuropathy in Germany: current evidence from clinical trials, Experimental & Clinical Endocrinology & Diabetes 1999;107(7):421-30.Ziegler C, et al: Alpha-lipoic acid in the treatment of diabetic neuropathy in Germany: current evidence from clinical trials, Experimental & Clinical Endocrinology & Diabetes 1999;107(7):421-30.Gregus Z, et al: Effect of lipoic acid on biliary excretion of glutathione and metals, Toxicology & Applied Pharmacology 1992 May;114(1):88-96.

Taurine:

Enhances biliary excretion, protects CNS , retina, and white blood cells.
Taurine is a conditionally essential sulfur containing amino acid found in meat, fish, eggs and dairy products that appears to function as a neuromodulator and protective antioxidant in the CNS, where it is present in large amounts. Taurine levels are reduced in patients with lead poisoning. Taurine also protects the kidneys and retina from free radical damage by toxic metals and also protects the liver, heart, lungs and neutrophiles. Taurine has also been shown to enhance the secretion of toxic metals in bile. Chesney, R.W. et al: Role of taurine in infant nutrition, Adv Exp Med Biol 1998 442: 463-76. Stapleton PP et al: Host Defense – a role for the amino acid taurine? J Parenter Enteral Nutr. 1998 Jan-Feb;22(1):42-8.
Schuller-Levis GB, Park E: Taurine- new implications for an old amino acid. FEMS Microbiol Lett. 2003 Sep 26;226(2):195-202. Redmond HP et al. Immunonutrition – the role of taurine. Nutrition 1998 Jul-Aug; 14(7-8):599-604 Kontny E et al:The mechanism of taurine –choramine inhibition of cytokine production by rheumatoid arthritis fibroblast-like synoviocytes; Arthritis Rheum 2000 Oct,43(10):169-77.

Chlorella:
Traps toxic metals in the GI tract. Acts as an ion exchange resin Chlorella is a species of unicellular fresh water algae that has been shown to possess detoxifying properties enabling it to assist or support the human detoxification system. Chlorella algae contain phytochemicals that support Phase I and Phase II detoxification reactions while the cell walls function as an ion exchange resin to absorb and retain toxic metals which can then be excreted. Chlorella can be used as a significant source of nutrients including vitamins, amino acids, fatty acids and minerals. They possess no toxicity and 20 grams or more can be ingested daily without any adverse effect. H.B.Xue, W.Stumm, L.Sigg: The binding of Heavy Metals to Algal Surfaces, Water Res 1988;22, 917Carr HP, et al. Characterization of the cadmium-binding capacity of Chlorella vulgaris. Bull Environ Contam Toxicol. 1998;60(3): 433-440M.Kraft: Bindungsverhalten von Arsen, Cadmium, Chrom, Quecksilber, Nickel und Blei an schwerverdauliche Lebensmittel und Lebensmittelkomponenten in kuenstlichem Magen-Darm-Saft. PhD Thesis. Institut fuer Hygiene, Sozial-und umweltmedizin der Ruhr-Universitaet Bochum, Germany, (1998)Ahner, AB, Kong KS, Morell MM, Phytochelatin production in marine algea: An interspecies comparison. Limnol Oceanograph 1995;40: 649-657Northcote DH et al, 1958 The chemical composition and structure of the cell wall of Chlorella pyrenoidosa. .Biochem J 70:391-97.
Travieso RO et al. 1999Heavy Metal Removal by microalgae. Bull. Environ.Contam.Toxicol.62:144-151.


Cilantro
(aerial parts) (from 10:1 extract):
Mobilizes toxic metals from the central nervous system and other tissues Cilantro is a vegetable in the parsley family shown by Omura and others to be an effective chelator of CNS toxic metals. Its active component is a mercaptan that can penetrate the blood brain barrier. Omura Y, Beckman SL Role of mercury (Hg) in resistant infections & effective treatment of Chlamydia trachomatis and Herpes family viral infections (and potential treatment for cancer) by removing localized Hg deposits with Chinese parsley and delivering effective antibiotics using various drug uptake enhancement methods. Acupunct Electrother Res. 1995;20(3-4): 195-229Omura Y, Shimotsuura Y, Fukuoka A, Fukuoka H, Nomoto T. Significant mercury deposits in internal organs following the removal of dental amalgam, & development of pre-cancer on the gingiva and the sides of the tongue and their represented organs as a result of inadvertent exposure to strong curing light (used to solidify synthetic dental filling material) & effective treatment: a clinical case report, along with organ representation areas for each tooth. Acupunct Electrother Res. 1996 ;21(2): 133-16098 Ewan KB, Pamphlett R Increased inorganic mercury in spinal motor neurons following chelating agents. Neurotoxicology 1996;17(2):343-349

MSM
(methylsulfonylmethane):
Enhances permeability of cell membranes and reduces inflammation Methyl sulfonyl methane or MSM is a naturally occurring sulfur containing molecule found in fruits, vegetables, seafood and meat. It is present in the body and humans excrete from 4-11 mg. daily in urine. Research suggests that it is required for the body to preserve normal function and structure. Its toxicity is about equal to water. Food processing destroys the MSM normally present in food. MSM aids in detoxifying metals by contributing sulfur to methionine and cysteine as well as peptides and proteins and is eventually incorporated into connective tissue. It is also believed to enhance detoxification by increasing the permeability of cell walls. Recommended dosage for continuous use is 3000-6000 mg/day. When starting MSM some individuals may experience transient diarrhea, headache, skin rash, or fatigue associated with the release of toxins. Jacob, Stanley W, M.D., Lawrence, Ronald M, M.D., PhD, Zucker, Martin The Miracle of MSM, The Natural Solution for Pain New York: Berkley Books 1999

L-Glutamine:
Restores and preserves gastro-intestinal function, enhances hair excretion, glutathione precursor Glutamine is utilized as a source of energy and for nucleotide synthesis in all rapidly dividing cells. Hair follicles depend on it for energy production so that it assists the hair follicle in excreting toxic metals and the lining of the intestine in resisting the effects of toxic metals. It also is involved in the detoxification of ammonia, which reduces ATP production and thus ammonia interferes with detoxification reactions that depend on adequate supplies of ATP. Toxic metal poisoning frequently interferes with the regulation of glucose levels in the body, increasing susceptibility to hypoglycemia. Glutamine can prevent hypoglycemia since it is easily converted in glucose. Glutamine is a substrate for glutathione, which plays a major role in the body’s antioxidant and detoxification defenses. Both glutamine and glutathione are reduced in lead toxicity. Williams R. et al; Metabolism of freshly isolated human hair follicles capable of hair elongation: a glutaminolytic aerobic glucolytic tissue; J Invest Dermatol. 1993 June; 100(6):834-40 Fox AD et al; Effect of a glutamine-supplemented enteral diet on methotrexate induced enterocolitis. J Parenter Enteral Nutr. 1988 Jul-Aug, 12(4):325-31Cao Y et al ;Glutamine enhances gut glutathione production; J Parenter Enteral Nutr.1998 Jul-Aug; 22(4):224-7 Wessner B, et al; Effect of single and combined supply of glutamine, glycine, n- acetylcysteine and R,S alpha lipoic acid on glutathione content of myelomonocytic cells. Clin Nutr. 2003 Dec;22(6):515-22.

NAC
(N-Acetylcysteine):
Binds toxic metals, raises glutathione levels and acts as antioxidant. Yim CY, et al: Use of N-acetylcysteine to increase intracellular glutathione during induction of antitumor responses by IL-2, Journal of Immunology, 1994 Jan 15; 152(12):5796-805.Meyer A, Buhl R, Magnussen H: The effect of oral N-acetylcysteine on lung glutathione levels in idiopathic pulmonary fibrosis, European Respiratory Journal, 1994 Mar; 7(3):431-6